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The address of a cell in Excel is determined by the column letter and the row number. The third column (C) and second row (2) intersect at cell C2. Knowledge Booster: 1. Column letters range from A to Z and beyond (AA, AB, etc.). 2. Row numbers are numerical (1, 2, 3, etc.). 3. Proper cell referencing is key for accurate formulas. 4. Combined use of relative and absolute references improves data management.